منابع مشابه
SHRiMP2: Sensitive yet Practical Short Read Mapping
UNLABELLED We report on a major update (version 2) of the original SHort Read Mapping Program (SHRiMP). SHRiMP2 primarily targets mapping sensitivity, and is able to achieve high accuracy at a very reasonable speed. SHRiMP2 supports both letter space and color space (AB/SOLiD) reads, enables for direct alignment of paired reads and uses parallel computation to fully utilize multi-core architect...
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We present a theory for the construction of an optimal matched lter for self-motion induced optic ow elds. The matched lter extracts local ow components along a set of pre-deened directions and weights them according to an optimization principle which minimizes the diierence between estimated and real egomotion parameters. In contrast to previous approaches, prior knowledge about distance and t...
متن کاملGenome-wide screen for oxalate-sensitive mutants of Saccharomyces cerevisiae.
Oxalic acid is an important virulence factor produced by phytopathogenic filamentous fungi. In order to discover yeast genes whose orthologs in the pathogen may confer self-tolerance and whose plant orthologs may protect the host, a Saccharomyces cerevisiae deletion library consisting of 4,827 haploid mutants harboring deletions in nonessential genes was screened for growth inhibition and survi...
متن کاملGenome-wide synteny through highly sensitive sequence alignment: Satsuma
MOTIVATION Comparative genomics heavily relies on alignments of large and often complex DNA sequences. From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes). RESULTS Satsuma addresses all three issues through novel s...
متن کاملFast, Sensitive Discovery of Conserved Genome-Wide Motifs
Regulatory sites that control gene expression are essential to the proper functioning of cells, and identifying them is critical for modeling regulatory networks. We have developed Magma (Multiple Aligner of Genomic Multiple Alignments), a software tool for multiple species, multiple gene motif discovery. Magma identifies putative regulatory sites that are conserved across multiple species and ...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.326_773b